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KMID : 0354720070310020144
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Journal of Korean Diabetes Association
2007 Volume.31 No. 2 p.144 ~ p.150
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Transforming Growth Factor-beta 1 Gene Polymorphisms According to Diabetic Nephropathy in Type 2 Diabetes
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Jeon Hwang-Gyun
Kim Ok-Hee
Kim Ho
Kwon Soon-Kil
Oh Tae-Geun
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Abstract
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Background: Transforming growth factor-β is known to play a role in the interaction between metabolic and hemodynamic factors in mediating accumulation of extracellular matrix in the diabetic nephropathy. TGF-β1 gene polymorphism was associated with circulating TGF-β levels and influenced the pathogenesis of fibrotic diseases including diabetic nephropathy. In this study, we examined the relationship between TGF-β1 gene codon 10 polymorphism and type 2 diabetic nephropathy with more than 10-year history of disease.
Methods: We conducted a case-control study, which enrolled 325 type 2 diabetes. A total of 176 patients with diabetic nephropathy were compared with 149 patients without diabetic nephropathy. TGF-β1 codon 10 genotyping was determined using polymerase chain reaction with sequence specific primers method.
Results: Distribution of TGF-β1 codon 10 genotype in the patients either with nephropathy or without nephropathy is confined to Hardy-Weinberg equilibrium. The patients with nephropathy have higher frequency of TGF-β1 GA/GG genotypes than the patients without nephropathy [GA/GG:AA = 119 (67.6%) : 57 (32.4%) vs. 80 (53.7%) : 69 (46.3%), P < 0.05]. Among patients with diabetic nephropathy, those with TGF-β1 GA/GG genotypes had higher serum levels of total cholesterol and LDL-cholesterol.
Conclusion: Our results suggest that TGF-β1 gene codon 10 polymorphism may contribute to the type 2 diabetic nephropathy.
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KEYWORD
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Diabetic nephropathy, TGF-β1 polymorphism, Type 2 diabetes
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